Drug Information

Drug General Information
Drug ID
D0U7PS
Former ID
DCL000375
Drug Name
GSK256066
Synonyms
GSK-256066
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease; Asthma [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Discontinued in Phase 2 [548294]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C27H26N4O5S
Canonical SMILES
CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C<br />=N2)C(=O)N)NC4=CC(=CC=C4)OC
InChI
1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30)
InChIKey
JFHROPTYMMSOLG-UHFFFAOYSA-N
PubChem Compound ID
9827968
PubChem Substance ID
14787174, 24129924, 44926098, 75157187, 103704123, 124360777, 125164690, 125653374, 131326858, 134339024, 136340322, 136349521, 136367652, 136920333, 137685009, 144116030, 152258227, 160647063, 162011384, 162038031, 162202759, 163364025, 163642651, 163913562, 164194085, 170482606, 174006286, 174530826, 180191800, 185998827, 198983498, 223682017, 223705159, 227387094, 242059766, 242591500, 247189701, 251963086, 251971295, 252110118, 252215508, 252449266, 252451559
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [550963]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addiction
Reactome DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
References
Ref 548294Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024245)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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