Drug Information

Drug General Information
Drug ID
D0U7UD
Former ID
DNC011043
Drug Name
5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551219]
Structure
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2D MOL

3D MOL
Formula
C14H12ClN3O
Canonical SMILES
C1CN(C2=C1C=C(C=C2)Cl)C(=O)NC3=CN=CC=C3
InChI
1S/C14H12ClN3O/c15-11-3-4-13-10(8-11)5-7-18(13)14(19)17-12-2-1-6-16-9-12/h1-4,6,8-9H,5,7H2,(H,17,19)
InChIKey
BYXYRVSXGVLRKM-UHFFFAOYSA-N
PubChem Compound ID
10826147
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [551219]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [551219]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 551219Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.
Ref 551219Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.

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