Drug General Information
Drug ID
D0U8AS
Former ID
DNCL002514
Drug Name
Telapristone
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Phase 2 [547243]
Company
Repros Therapeutics
Structure
Download
2D MOL

3D MOL

Formula
C31H39NO5
Canonical SMILES
CC(=O)OC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)<br />N(C)C)C)C(=O)COC
InChI
1S/C31H39NO5/c1-19(33)37-31(28(35)18-36-5)15-14-27-25-12-8-21-16-23(34)11-13-24(21)29(25)26(17-30(27,31)2)20-6-9-22(10-7-20)32(3)4/h6-7,9-10,16,25-27H,8,11-15,17-18H2,1-5H3/t25-,26+,27-,30-,31-/m0/s1
InChIKey
JVBGZFRPTRKSBB-MJBQOYBXSA-N
CAS Number
CAS 198414-31-2
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Progesterone receptor Target Info Antagonist [527064]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 547243Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014404)
Ref 527064In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88.

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