Drug Information

Drug General Information
Drug ID
D0U9HE
Former ID
DNC008999
Drug Name
RS-102,221
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539175]
Structure
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2D MOL

3D MOL
Formula
C27H31F3N4O7S
InChI
InChI=1S/C27H31F3N4O7S/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37)
InChIKey
HZZZZODVDSHQRG-UHFFFAOYSA-N
PubChem Compound ID
3693566
PubChem Substance ID
5077657, 7980543, 9839311, 11113883, 14813987, 26752046, 40412699, 47731305, 48179777, 48329120, 48404537, 57356487, 78482518, 85209271, 85788130, 103299767, 112149552, 126275069, 128137706, 134223914, 134346204, 135650934, 136351198, 225031832, 232761191
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [529789]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539175(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 187).
Ref 529789J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

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