Drug Information

Drug General Information
Drug ID
D0U9QL
Former ID
DNC000023
Drug Name
[Nphe(1)]-nociceptin (1-13)-NH(2)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539050]
Structure
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2D MOL

3D MOL
Formula
C21H27F2N4O6P
Canonical SMILES
CN1C=C(C(=N1)C(F)F)C(=O)NC2=CC=CC=C2C3CC3C4CC4.C(C(=O)O<br />)NCP(=O)(O)O
InChI
1S/C18H19F2N3O.C3H8NO5P/c1-23-9-14(16(22-23)17(19)20)18(24)21-15-5-3-2-4-11(15)13-8-12(13)10-6-7-10;5-3(6)1-4-2-10(7,8)9/h2-5,9-10,12-13,17H,6-8H2,1H3,(H,21,24);4H,1-2H2,(H,5,6)(H2,7,8,9)
InChIKey
ZLEQCJLOZSQAHT-UHFFFAOYSA-N
CAS Number
CAS 1071-83-6
PubChem Compound ID
24776433
PubChem Substance ID
49701090, 134339573, 134339574
ChEBI ID
ChEBI:27744
Target and Pathway
Target(s) Nociceptin receptor Target Info Antagonist [535360]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539050(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1695).
Ref 535360Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test. Naunyn Schmiedebergs Arch Pharmacol. 2002 Feb;365(2):164-7. Epub 2001 Dec 20.

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