Drug General Information
Drug ID	D0UB6U
Former ID	DNC012251
Drug Name	L-687414
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[544996]
Structure		Download 2D MOL 3D MOL
Formula	C5H10N2O2
Canonical SMILES	CC1CN(C(=O)C1N)O
InChI	1S/C5H10N2O2/c1-3-2-7(9)5(8)4(3)6/h3-4,9H,2,6H2,1H3/t3-,4-/m1/s1
InChIKey	SKYSFPFYQBZGDC-QWWZWVQMSA-N
PubChem Compound ID	10313147
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[551249]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[551249]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[551249]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Huntington's disease
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
	Reelin signaling pathway
Reactome	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 544996	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001829)
Ref 551249	Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993).

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