Drug General Information
Drug ID
D0UL2H
Former ID
DIB003588
Drug Name
Androgen restored contraceptive
Synonyms
A-ENDO; ARC, Pantarhei; Androgen restored contraceptive (oral, contraception); Androgen restored contraceptive (oral, contraception), Pantarhei; Drug combination (oral, endometriosis), Pantarhei; Androgen/estrogen/progestogen combination (oral, endometriosis), Pantarhei; Dehydroepiandrosterone/estrogen/progestogen combination (oral, endometriosis), Pantarhei
Indication Contraception [ICD10:Z30] Phase 2 [527054]
Company
Pantarhei Bioscience BV
Target and Pathway
Target(s) Androgen receptor Target Info Agonist [551483]
Progesterone receptor Target Info Agonist [551483]
Estrogen receptor Target Info Agonist [543898]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04114:Oocyte meiosis
Progesterone-mediated oocyte maturationhsa04915:Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling PathwayNetPath_25:FSH Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networkanthraxpathway:Cellular roles of Anthrax toxinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1251985:Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-1251985:Nuclear signaling by ERBB4
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP34:Ovarian Infertility Genes
Signaling by ERBB4
Nuclear ReceptorsWP712:Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
JAK/STAT
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
References
Ref 527054Treatment outcome in endodontics-the Toronto Study. Phase II: initial treatment. J Endod. 2004 May;30(5):302-9.
Ref 543898(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
Ref 551483Clinical pipeline report, company report or official report of Pantarhei Bioscience .

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