Drug General Information
Drug ID	D0V1HA
Former ID	DNC013433
Drug Name	N-hydroxy-3-(naphthalen-1-yl)acrylamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528719]
Structure		Download 2D MOL 3D MOL
Formula	C13H11NO2
Canonical SMILES	C1=CC=C2C(=C1)C=CC=C2C=CC(=O)NO
InChI	1S/C13H11NO2/c15-13(14-16)9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-9,16H,(H,14,15)/b9-8+
InChIKey	AOXOYUCWJCCUDO-CMDGGOBGSA-N
PubChem Compound ID	24880249
Target and Pathway
Target(s)	Histone Deacetylase 8	Target Info	Inhibitor	[528719]
KEGG Pathway	Alcoholism
	Viral carcinogenesis
PANTHER Pathway	Wnt signaling pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class I
Reactome	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histones
WikiPathways	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	Cell Cycle
References
Ref 528719	Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Ref 528719	Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.

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