Drug General Information
Drug ID	D0V3WQ
Former ID	DIB010349
Drug Name	Sch-207758
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Terminated	[547062]
Company	Schering-Plough Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c3c([nH]cc3C)c(cc2CCc2c([C@@H]1C1CCN(C(=O)Cc3cc[n+](<br />[O-])cc3)CC1)nccc2)Cl
CAS Number	CAS 410074-09-8
Target and Pathway
Target(s)	Protein farnesyltransferase beta subunit	Target Info	Inhibitor	[526408]
KEGG Pathway	Terpenoid backbone biosynthesis
	Biosynthesis of antibiotics
NetPath Pathway	TSH Signaling Pathway
Reactome	Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways	Visual phototransduction
References
Ref 547062	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012642)
Ref 526408	Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase. J Med Chem. 2002 Aug 29;45(18):3854-64.

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