Drug Information

Drug General Information
Drug ID
D0V3ZA
Former ID
DAP000078
Drug Name
Dihydroergotamine
Synonyms
Agit; Angionorm; DIHYDROERGOTOXINE; Dehydroergotamine; Dergotamine; Diergo; Dihidroergotamina; Dihydergot; Dihydroergotaminum; Dihydroergotoxin; Diidroergotamina; Dirgotarl; Endophleban; Ergomimet; Ergont; Ergotonin; Ikaran; Migranal; Morena; Neomigran; Orstanorm; Seglor; Tonopres; Verladyn; DET MS; Dihydroergotamine methanesulfonate; Diidroergotamina [DCIT]; Ergoloid dihydroergotoxine; Co-Dergocrine; DHE-45; Dihidroergotamina [INN-Spanish]; Dihydroergotamine (INN); Dihydroergotaminum [INN-Latin]; ErgoloidMesylates (dihydroergotoxine); Ergot Alkaloids, Hydrogenated; Migranal (TN); Neomigran (TN); (10alphaH)-5'alpha-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman; (5'alpha)-12'-Hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione; (5'alpha)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman; 5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman; 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione; 9,10-Dihydroergotamine; 9,10-dihydro-ergotamine
Drug Type
Small molecular drug
Indication Migraine headaches [ICD9: 346; ICD10:G43] Approved [537885], [538723]
Therapeutic Class
Antimigraine Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C33H37N5O5
InChI
InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1
InChIKey
LUZRJRNZXALNLM-JGRZULCMSA-N
CAS Number
CAS 6190-39-2
PubChem Compound ID
10531
PubChem Substance ID
10000, 7979087, 8157604, 11335767, 11361006, 11363951, 11366513, 11369075, 11371529, 11374714, 11377237, 11461978, 11484971, 11489004, 11490211, 11492773, 11494871, 14788984, 14935810, 29229015, 46507711, 47291112, 47885391, 48110437, 48334472, 49963030, 49965612, 50153282, 57326281, 85789540, 90341683, 93166278, 96024534, 99313633, 103684622, 103905875, 104137088, 104171355, 104323551, 119501400, 124749650, 124883197, 124883198, 126688923, 127323995, 127323996, 127323997, 127323998, 127323999, 127324000
SuperDrug ATC ID
N02CA01
SuperDrug CAS ID
cas=000511126
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [536777]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 537885Migraine: a pharmacologic review with newer options and delivery modalities. Neurology. 1994 May;44(5 Suppl 3):S13-7.
Ref 538723(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 121).
Ref 536777Current and prospective pharmacological targets in relation to antimigraine action. Naunyn Schmiedebergs Arch Pharmacol. 2008 Oct;378(4):371-94. Epub 2008 Jul 15.

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