TTD | Drug: D0V3ZG

Drug General Information
Drug ID	D0V3ZG
Former ID	DIB020837
Drug Name	RO5101576
Synonyms	Ro 5101576
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541348]
Structure		Download 2D MOL
Formula	C36H38O8S
InChI	InChI=1S/C36H38O8S/c37-35(38)10-6-17-42-32-9-5-8-25(31(32)12-14-36(39)40)7-3-1-2-4-16-41-30-20-28(19-29(21-30)27-15-18-45-23-27)26-11-13-33-34(22-26)44-24-43-33/h5,8-9,11,13,15,18-23H,1-4,6-7,10,12,14,16-17,24H2,(H,37,38)(H,39,40)
InChIKey	SRPFDFNVILUDAI-UHFFFAOYSA-N
PubChem Compound ID	25192022
PubChem Substance ID	57300655, 85035777, 103753127, 104151987, 137398055, 178102779, 224251401, 227874624, 244410028
Target and Pathway
Target(s)	Leukotriene B4 receptor 2	Target Info	Antagonist	[530774]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 541348	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6158).
Ref 530774	Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):33-43.

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Drug Information