Drug Information

Drug General Information
Drug ID
D0V4EX
Former ID
DIB003792
Drug Name
AC-710
Synonyms
CSF1R inhibitor (cancer), Ambit Biosciences; CSF1R inhibitor (cancer/autoimmune/inflammatory disease), Ambit Biosciences
Drug Type
Small molecular drug
Indication Autoimmune diabetes [ICD10:E08-E13] Investigative [542968]
Company
Ambit Biosciences Corp
Structure
Download
2D MOL

3D MOL
Formula
C31H42N6O4
InChI
InChI=1S/C31H42N6O4/c1-9-37-30(5,6)17-23(18-31(37,7)8)40-22-14-15-24(32-19-22)27(38)33-20-10-12-21(13-11-20)34-28(39)35-26-16-25(41-36-26)29(2,3)4/h10-16,19,23H,9,17-18H2,1-8H3,(H,33,38)(H2,34,35,36,39)
InChIKey
JVCWPUFNLFSKFS-UHFFFAOYSA-N
PubChem Compound ID
54760053
PubChem Substance ID
163318820, 163349626, 163492168, 227882869, 249565775, 252158533, 252669837
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Inhibitor [543466]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 542968(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8095).
Ref 543466(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.