Drug Information

Drug General Information
Drug ID
D0V4FW
Former ID
DNC010225
Drug Name
{2-[3-(Phenylsulfonyl)-1H-indol-4-yl]ethyl}amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530455]
Structure
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2D MOL

3D MOL
Formula
C16H16N2O2S
Canonical SMILES
C1=CC=C(C=C1)S(=O)(=O)C2=CNC3=CC=CC(=C32)CCN
InChI
1S/C16H16N2O2S/c17-10-9-12-5-4-8-14-16(12)15(11-18-14)21(19,20)13-6-2-1-3-7-13/h1-8,11,18H,9-10,17H2
InChIKey
RSVUNKKDIROCQS-UHFFFAOYSA-N
PubChem Compound ID
24861406
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [530455]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 530455Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. Epub 2009 Sep 18.Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
Ref 530455Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. Epub 2009 Sep 18.Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

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