Drug Information

Drug General Information
Drug ID
D0V4WT
Former ID
DIB020644
Drug Name
paxilline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539460]
Structure
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2D MOL

3D MOL
Formula
C27H33NO4
InChI
InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3
InChIKey
ACNHBCIZLNNLRS-UHFFFAOYSA-N
PubChem Compound ID
4697
PubChem Substance ID
237968, 5601114, 8152883, 24898374, 29223783, 50113170, 51626970, 57322403, 85088486, 104307162, 125768043, 135650789, 136352363, 162227105, 163046200, 179148745, 250129680
Target and Pathway
Target(s) Maxi K potassium channel Target Info Blocker (channel blocker) [534285]
Oxysterols receptor LXR-alpha Target Info Agonist [526684]
KEGG Pathway cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Insulin secretion
Salivary secretion
Pancreatic secretionhsa03320:PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome cGMP effects
WikiPathways Potassium Channels
Platelet homeostasisWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 539460(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2309).
Ref 526684A natural product ligand of the oxysterol receptor, liver X receptor. J Pharmacol Exp Ther. 2003 Oct;307(1):291-6. Epub 2003 Jul 31.
Ref 534285Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology. 1996;35(7):963-8.

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