Drug General Information
Drug ID	D0V6NX
Former ID	DIB005822
Drug Name	P2X7 antagonists
Synonyms	P2X7 antagonists (pain); P2X7 antagonists (pain), GlaxoSmithKline
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Investigative	[552150]
Company	GlaxoSmithKline plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1([C@@H](CNC1=O)C(=O)NCc1c(cc(cc1)Cl)Cl)C
Target and Pathway
Target(s)	P2X purinoceptor 7	Target Info	Antagonist	[543850]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
Reactome	The NLRP3 inflammasome
WikiPathways	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 552150	Paradoxical P2X7. Baas, T. SciBX 5(20).
Ref 543850	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484).

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