Drug Information

Drug General Information
Drug ID
D0V8PA
Former ID
DNC008434
Drug Name
NERIDRONIC ACID
Drug Type
Small molecular drug
Indication Bone disease [ICD10:M00-M99] Approved [551871]
Structure
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2D MOL

3D MOL
Formula
C6H17NO7P2
Canonical SMILES
C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
InChI
1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)
InChIKey
PUUSSSIBPPTKTP-UHFFFAOYSA-N
CAS Number
CAS 79778-41-9
PubChem Compound ID
71237
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [529362]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 529362J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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