Drug Information

Drug General Information
Drug ID
D0V9XE
Former ID
DIB020910
Drug Name
SB236057
Synonyms
SB 236057; SB-236057
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540207]
Structure
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2D MOL

3D MOL
Formula
C33H34N4O3
InChI
InChI=1S/C33H34N4O3/c1-4-36-15-12-33(13-16-36)20-39-30-18-25-11-14-37(29(25)19-28(30)33)32(38)24-7-5-23(6-8-24)27-10-9-26(17-21(27)2)31-35-34-22(3)40-31/h5-10,17-19H,4,11-16,20H2,1-3H3
InChIKey
WXAKEEQOWUHGCI-UHFFFAOYSA-N
PubChem Compound ID
5311426
PubChem Substance ID
7980572, 11056497, 14812141, 39341102, 53406949, 85209287, 114156064, 124954239, 124972114, 129646685, 134340493, 135650997, 225058099, 233400340
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [525557]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540207(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3231).
Ref 525557SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor. Eur J Pharmacol. 1999 Jun 30;375(1-3):359-65.

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