Drug Information

Drug General Information
Drug ID
D0VE0Q
Former ID
DNC007645
Drug Name
Sophoraflavanone G
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528742]
Structure
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2D MOL

3D MOL
Formula
C25H28O6
Canonical SMILES
CC(=CCC(CC1=C(C=C(C2=C1OC(CC2=O)C3=C(C=C(C=C3)O)O)O)O)C<br />(=C)C)C
InChI
1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3/t15-,23+/m1/s1
InChIKey
XRYVAQQLDYTHCL-CMJOXMDJSA-N
PubChem Compound ID
72936
Target and Pathway
Target(s) mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [528742]
Sodium/glucose cotransporter 1 Target Info Inhibitor [528742]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP2884:NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydrates
References
Ref 528742Bioorg Med Chem. 2007 May 15;15(10):3445-9. Epub 2007 Mar 12.Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.
Ref 528742Bioorg Med Chem. 2007 May 15;15(10):3445-9. Epub 2007 Mar 12.Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.

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