Drug Information

Drug General Information
Drug ID
D0W0TH
Former ID
DNC001187
Drug Name
R 80122
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Discontinued in Phase 1 [544843]
Structure
Download
2D MOL

3D MOL
Formula
C26H29N5O3
Canonical SMILES
CN(C1CCCCC1)C(=O)CON=C(C2=CC=CC=C2)C3=CC4=C(C=C3)NC5=NC<br />(=O)CN5C4
InChI
1S/C26H29N5O3/c1-30(21-10-6-3-7-11-21)24(33)17-34-29-25(18-8-4-2-5-9-18)19-12-13-22-20(14-19)15-31-16-23(32)28-26(31)27-22/h2,4-5,8-9,12-14,21H,3,6-7,10-11,15-17H2,1H3,(H,27,28,32)/b29-25+
InChIKey
VHDUUXNHZLBGHQ-XLVZBRSZSA-N
CAS Number
CAS 133718-29-3
PubChem Compound ID
9571043
PubChem Substance ID
14906953, 44709239, 51184013, 57372914, 134340411, 135026071, 160708911, 180371851, 198947952, 226414820, 232928726, 241032141
Target and Pathway
Target(s) Phosphodiesterase (PDE) 3 Target Info Modulator [535804]
References
Ref 544843Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001304)
Ref 535804Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J Pharmacol Exp Ther. 1992 Oct;263(1):6-14.

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