Drug Information

Drug General Information
Drug ID
D0W1HM
Former ID
DIB020486
Drug Name
nafadotride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467711]
Structure
Download
2D MOL
Formula
C22H27N3O2
InChI
InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)
InChIKey
IDZASIQMRGPBCQ-UHFFFAOYSA-N
PubChem Compound ID
3408722
PubChem Substance ID
4546259, 7980060, 9949320, 14877084, 26719799, 36278386, 46387001, 49681626, 50070521, 50071159, 53746209, 56311648, 57309748, 57356263, 85209195, 85789022, 92308559, 103195448, 104024628, 112212992, 124659097, 124800019, 125666021, 128154304, 135305572, 135610838, 135650679, 135698262, 139676272, 144235422, 162022313, 162023065, 163145133, 163751395, 172080492, 178125929, 179296009, 179323700, 184538718, 202558049, 219812685, 226935689, 241182349, 249617290, 252126122, 252270535, 252360576
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Antagonist [534073]
D(2) dopamine receptor Target Info Antagonist [534073]
D(4) dopamine receptor Target Info Antagonist [525665]
5-hydroxytryptamine 1A receptor Target Info Agonist [534714]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
References
Ref 467711(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 44).
Ref 525665Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol. 2000 Jan;57(1):144-52.
Ref 534073Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther. 1995 Dec;275(3):1239-46.
Ref 534714Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56.

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