Drug Information

Drug General Information
Drug ID
D0W2OT
Former ID
DNC008058
Drug Name
BUTAPROST
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540327]
Structure
Download
2D MOL

3D MOL
Formula
C24H40O5
InChI
InChI=1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19-,21-,22-/m1/s1
InChIKey
XRISENIKJUKIHD-LHQZMKCDSA-N
PubChem Compound ID
5311035
PubChem Substance ID
7978831, 11056221, 14830960, 14981265, 17397341, 24724423, 29217509, 39340764, 47289029, 51208537, 53790190, 57359331, 71840282, 103573820, 114155103, 135029627, 135650037, 136351702, 137263492, 144207029, 162248341, 179150960, 198951555, 226472196, 252322127, 252463361
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Inhibitor [529174]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540327(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3379).
Ref 529174Bioorg Med Chem Lett. 2008 Jan 15;18(2):821-4. Epub 2007 Nov 13.Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.