Drug General Information
Drug ID	D0W3IQ
Former ID	DNC013159
Drug Name	D[Val4]AVP
Indication	Discovery agent		Investigative	[528674]
Structure		Download 2D MOL 3D MOL
Formula	C46H65N13O11S2
PubChem Compound ID	44419025
Target and Pathway
Target(s)	Vasopressin V2 receptor	Target Info	Inhibitor	[528674]
	Oxytocin receptor	Target Info	Inhibitor	[528674]
	Vasopressin V1b receptor	Target Info	Inhibitor	[528674]
	Vasopressin V1a receptor	Target Info	Inhibitor	[528674]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	Oxytocin signaling pathwayhsa04020:Calcium signaling pathway
	Vascular smooth muscle contractionhsa04020:Calcium signaling pathway
	Vascular smooth muscle contraction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Oxytocin receptor mediated signaling pathway
Pathway Interaction Database	Arf6 trafficking events
PathWhiz Pathway	Vasopressin Regulation of Water Homeostasis
Reactome	Vasopressin-like receptors
	G alpha (s) signalling events
	Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors
	G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Regulation of Water Balance by Renal Aquaporins
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	Myometrial Relaxation and Contraction Pathways
	Oxytocin signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
References
Ref 528674	J Med Chem. 2007 Feb 22;50(4):835-47.Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.
Ref 528674	J Med Chem. 2007 Feb 22;50(4):835-47.Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.

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