Drug Information

Drug General Information
Drug ID
D0W4ZU
Former ID
DNC012053
Drug Name
KURARINOL
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526395]
Structure
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2D MOL

3D MOL
Formula
C26H32O7
Canonical SMILES
CC(=C)C(CCC(C)(C)O)CC1=C(C=C(C2=C1OC(CC2=O)C3=C(C=C(C=C<br />3)O)O)OC)O
InChI
1S/C26H32O7/c1-14(2)15(8-9-26(3,4)31)10-18-20(29)12-23(32-5)24-21(30)13-22(33-25(18)24)17-7-6-16(27)11-19(17)28/h6-7,11-12,15,22,27-29,31H,1,8-10,13H2,2-5H3/t15-,22+/m1/s1
InChIKey
XMUPAAIHKAIUSU-QRQCRPRQSA-N
PubChem Compound ID
44563198
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [526395]
CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [526395]
CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [526395]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [526395]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
cGMP-PKG signaling pathwayhsa00230:Purine metabolism
cGMP-PKG signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-418457:cGMP effectsR-HSA-418457:cGMP effects
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP2005:miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 526395Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.
Ref 526395Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.

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