Drug Information

Drug General Information
Drug ID
D0W5RL
Former ID
DCL000705
Drug Name
Asoprisnil
Synonyms
J867; J-867; Asoprisnil (USAN/INN); 11beta-(4-((E)-(Hydroxyimino)methyl)phenyl)-17beta-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Discontinued in Phase 3 [536772], [539910]
Company
Bayer
Structure
Download
2D MOL

3D MOL
Formula
C28H35NO4
InChI
InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1
InChIKey
GJMNAFGEUJBOCE-MEQIQULJSA-N
CAS Number
CAS 199396-76-4
PubChem Compound ID
9577221
PubChem Substance ID
12014969, 14833248, 14881947, 17397152, 23998074, 44715211, 53249467, 57373120, 103568481, 134339207, 135112519, 135625927, 137249285, 141064982, 162220299, 198964838, 226440788, 252160354
Target and Pathway
Target(s) Progesterone receptor Target Info Modulator [536772]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 536772New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
Ref 539910(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2883).
Ref 536772New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.

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