Drug Information

Drug General Information
Drug ID
D0W6ZF
Former ID
DAP000694
Drug Name
Sevoflurane
Synonyms
Sevofluran; Sevoflurano; Sevofluranum; Sevofrane; Sevorane; Sojourn; Ultane; Fluoromethyl hexafluoroisopropyl ether; Bax 3084; F0691; MR6S4; MR_6S4; PC4681; Sevoflurano [INN-Spanish]; Sevofluranum [INN-Latin]; Ultane (TN); Sevoflurane (JAN/USAN/INN); Sevoflurane [USAN:INN:BAN:JAN]; Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether; Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [536300], [542316]
Therapeutic Class
Anesthetics
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C4H3F7O
InChI
InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2
InChIKey
DFEYYRMXOJXZRJ-UHFFFAOYSA-N
CAS Number
CAS 28523-86-6
PubChem Compound ID
5206
PubChem Substance ID
9723, 3215276, 6493020, 7847613, 7980594, 8153199, 12012762, 12075314, 15120951, 29224263, 46508591, 49968899, 50112674, 50769024, 57322653, 81065570, 85305373, 87560819, 92714283, 95693806, 99452954, 103770677, 104308565, 121362326, 125368119, 126624262, 126655524, 127726271, 131308872, 131465785, 134213127, 134337983, 134997737, 135589757, 137005407, 142416197, 143461391, 144076360, 144205978, 160810390, 160964568, 162177516, 162829968, 164791075, 174528671, 175268320, 175611312, 176247785, 178103869, 179116892
SuperDrug ATC ID
N01AB08
SuperDrug CAS ID
cas=028523866
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Antagonist [537113]
References
Ref 536300Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
Ref 542316(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7296).
Ref 537113Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35. Epub 2008 Dec 31.

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