Drug Information

Drug General Information
Drug ID
D0W8SB
Former ID
DAP000938
Drug Name
Penbutolol
Synonyms
Betapressin; Levatol; Levatolol; Levopenbutol; Lobeta; Paginol; Penbutololum; PENBUTOLOL SULFATE; HOE 893; HOE 893d; Betapressin (TN); Hostabloc (TN); L-Penbutolol; Levatol (TN); Levatolol (TN); Lobeta (TN); Paginol (TN); Penbutolol (INN); Penbutolol [INN:BAN]; Penbutololum [INN-Latin]; Penbutolol Sulfate (2:1); S(-)-Penbutolol; (-)-Penbutolol; (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol; 1-(tert-Butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol
Drug Type
Small molecular drug
Indication Hypertension; Angina pectoris [ICD9: 401, 413; ICD10:I10-I16, I20] Approved [537669], [542282], [551871]
Therapeutic Class
Antihypertensive Agents
Structure
Download
2D MOL

3D MOL
Formula
C18H29NO2
InChI
InChI=1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1
InChIKey
KQXKVJAGOJTNJS-HNNXBMFYSA-N
CAS Number
CAS 36507-48-9
PubChem Compound ID
37464
PubChem Substance ID
9620, 8175027, 15902888, 34678763, 46504929, 47291267, 47589134, 48416387, 50022970, 50064728, 57312048, 77621769, 96024764, 103293389, 103400617, 104326642, 117556859, 124954107, 128421871, 134223256, 134338213, 134999314, 135049302, 137001394, 142047536, 160964648, 175266991, 178103837, 179150414, 223440604, 226426442
SuperDrug ATC ID
C07AA23
SuperDrug CAS ID
cas=036507489
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [535478], [537649]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 537669Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism. J Clin Pharmacol. 1990 May;30(5):412-21.
Ref 542282(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7263).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535478beta-Adrenergic receptor blockers--a group of chiral drugs: different effects of each enantiomer. Ceska Slov Farm. 2002 May;51(3):121-8.
Ref 537649Decrease in penbutolol central response as a cause of changes in its serum protein binding. J Pharm Pharmacol. 1990 Mar;42(3):164-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.