Drug Information

Drug General Information
Drug ID
D0WD8M
Former ID
DAP001362
Drug Name
Connexyn
Synonyms
Estulic; Intuniv; Tenex; GUANFACINE HCL; Guanfacine hydrochloride; G 1043; LON 798; BS 100-141; Guanfacine hydrochloride [USAN:JAN]; SPD-503; Tenex (TN); BS-100-141; Guanfacine hydrochloride (JAN/USP); N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride; N-(Aminoiminomethyl)-2,6-dichlorophenylacetamide monohydrochloride; N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide hydrochloride; N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride; N-Amidino-2-(2,6-dichlorophenyl)acetamide monohydrochloride; N-carbamimidoyl-2-(2,6-dichlorphenyl)acetamidhydrochlorid; N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide hydrochloride; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1)
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Approved [550610]
Structure
Download
2D MOL

3D MOL
Formula
C9H10Cl3N3O
Canonical SMILES
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
InChI
1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
InChIKey
DGFYECXYGUIODH-UHFFFAOYSA-N
CAS Number
CAS 29110-47-2
PubChem Compound ID
71401
PubChem Substance ID
7847672, 10321692, 11532959, 12013435, 14799743, 17405082, 43127732, 49878427, 50106306, 50125709, 53777625, 56422899, 57318182, 75139922, 85273773, 91011797, 92125343, 92304014, 103770477, 103840710, 103914179, 104350375, 117464967, 124891653, 126657731, 131315423, 134338574, 135030202, 137074791, 144075859, 144203710, 152106277, 160838238, 162174779, 162247844, 163098785, 163135011, 163403921, 163564473, 163621092, 163686415, 164814341, 170465381, 172908369, 175266064, 175611116, 175611812, 179149181, 185983130, 196106983
SuperDrug ATC ID
C02AC02
SuperDrug CAS ID
cas=029110472
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Agonist [537472]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 550610Shire Announces NDA Submission of Guanfacine Extended Release for the Treatment of ADHD in Children and Adolescents, 2009. FDA Approved - September 2, 2009
Ref 537472Alpha(2A)-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience. 2009 Jun 12.

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