TTD | Drug: D0WH4H

Drug General Information
Drug ID	D0WH4H
Former ID	DIB018393
Drug Name	[3H]relcovaptan
Synonyms	[3H] SR 49059; [3H]SR49059; [3H]SR-49059
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540422]
Formula	C28H27Cl2N3O7S
InChI	InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1
InChIKey	CEBYCSRFKCEUSW-NAYZPBBASA-N
PubChem Compound ID	60943
Target and Pathway
Target(s)	Vasopressin V1a receptor	Target Info	Antagonist	[533909]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
Reactome	Vasopressin-like receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540422	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3482).
Ref 533909	Binding of [3H] SR 49059, a potent nonpeptide vasopressin V1a antagonist, to rat and human liver membranes. Biochem Biophys Res Commun. 1994 Feb 28;199(1):353-60.

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Drug Information