Drug Information

Drug General Information
Drug ID
D0WT7H
Former ID
DNC014121
Drug Name
Beta-funaltrexamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539006]
Structure
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2D MOL

3D MOL
Formula
C25H30N2O6
InChI
InChI=1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18-,23+,24+,25-/m1/s1
InChIKey
PQKHESYTSKMWFP-WZJCLRDWSA-N
PubChem Compound ID
5311018
PubChem Substance ID
7978777, 11056213, 26756546, 39340749, 47362873, 47734202, 49897049, 57359324, 79646302, 96024344, 103592778, 104102600, 134224261, 134351326, 135061935, 135649986, 139813944, 223446575, 227470376
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [530269]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539006(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1631).
Ref 530269J Med Chem. 2009 Dec 10;52(23):7372-5.Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.

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