Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X0WU
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| Former ID |
DIB011114
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| Drug Name |
Tolperisone
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| Synonyms |
Agileo; Viveo; AV-650; SPH-3047; Tolperisone (controlled-release); Tolperisone (controlled-release), Sanochemia; Tolperisone (controlled-release), Sanochemia/Avigen
|
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| Drug Type |
Small molecular drug
|
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| Indication | Muscle spasm [ICD10:M62.838] | Approved | [551871] | ||
| Company |
Sanochemia Pharmazeutika AG
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| Structure |
|
Download2D MOL |
|||
| Formula |
C16H24ClNO
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| Canonical SMILES |
C(=O)(C(CN1CCCCC1)C)c1ccc(cc1)C
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| CAS Number |
CAS 728-88-1
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Voltage-gated sodium channel | Target Info | Modulator | [527704], [551871] | |
| Voltage-dependent calcium channel | Target Info | Modulator | [527704], [530122] | ||
| References | |||||
| Ref 527704 | Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. Epub 2005 Aug 26. | ||||
| Ref 530122 | Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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