TTD | Drug: D0X2HK

Drug General Information
Drug ID	D0X2HK
Former ID	DNC009921
Drug Name	N-{4-[2-(4-Hydroxyphenyl)ethyl]phenyl}phthalimide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530220]
Structure		Download 2D MOL 3D MOL
Formula	C22H17NO3
Canonical SMILES	C1=CC=C2C(=C1)C(=O)N(C2=O)C3=CC=C(C=C3)CCC4=CC=C(C=C4)O
InChI	1S/C22H17NO3/c24-18-13-9-16(10-14-18)6-5-15-7-11-17(12-8-15)23-21(25)19-3-1-2-4-20(19)22(23)26/h1-4,7-14,24H,5-6H2
InChIKey	OFQPQJJVXCUPFR-UHFFFAOYSA-N
PubChem Compound ID	45481821
Target and Pathway
Target(s)	Oxysterols receptor LXR-alpha	Target Info	Inhibitor	[530220]
KEGG Pathway	PPAR signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hepatitis C
Pathway Interaction Database	RXR and RAR heterodimerization with other nuclear receptor
WikiPathways	Nuclear Receptors in Lipid Metabolism and Toxicity
	Nuclear Receptors Meta-Pathway
	PPAR Alpha Pathway
	Liver X Receptor Pathway
	Adipogenesis
	SREBF and miR33 in cholesterol and lipid homeostasis
	Nuclear Receptors
References
Ref 530220	Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. Epub 2009 Jun 2.Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.
Ref 530220	Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. Epub 2009 Jun 2.Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.

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Drug Information