Drug Information

Drug General Information
Drug ID
D0X2MZ
Former ID
DIB008805
Drug Name
Syn-1020
Synonyms
NOP agonist peptide (pain), SynVax; ORL1 agonist peptide (pain), SynVax; Ac-RY(3-Cl)YRWR-NH2
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [543766]
Company
Synvax Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
CC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N<br />[C@H](C(=O)N[C@H](C(=O)N)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)C<br />CCNC(=N)N)Cc1cc(c(cc1)O)Cl)Cc1ccc(cc1)O)CCCNC(=N)N
Target and Pathway
Target(s) Nociceptin receptor Target Info Agonist [543766]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).
Ref 543766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).

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