Drug Information

Drug General Information
Drug ID
D0X2TO
Former ID
DCL000680
Drug Name
Adatanserin
Synonyms
Adatanserin [INN]; WY 50324; N-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide
Drug Type
Small molecular drug
Indication Severe mood disorders [ICD9: 296; ICD10:F30-F39] Discontinued in Phase 2 [536580]
Company
Wyeth
Structure
Download
2D MOL

3D MOL
Formula
C21H31N5O
Canonical SMILES
C1CN(CCN1CCNC(=O)C23CC4CC(C2)CC(C4)C3)C5=NC=CC=N5
InChI
1S/C21H31N5O/c27-19(21-13-16-10-17(14-21)12-18(11-16)15-21)22-4-5-25-6-8-26(9-7-25)20-23-2-1-3-24-20/h1-3,16-18H,4-15H2,(H,22,27)
InChIKey
HPFLVTSWRFCPCV-UHFFFAOYSA-N
CAS Number
CAS 127266-56-2
PubChem Compound ID
130918
PubChem Substance ID
10242751, 14755285, 16906775, 29309413, 50338720, 57343599, 85210014, 103982986, 104373918, 128093388, 134339194, 135087154, 137147746, 140448709, 142709065, 143228052, 162219981, 179149754, 189299780, 198989586, 223705352, 226597195, 242105714, 242550065, 247062087
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534942], [536580]
5-hydroxytryptamine 2A receptor Target Info Antagonist [534942], [536580]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 534942Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. J Med Chem. 1999Dec 16;42(25):5077-94.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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