Drug General Information
Drug ID
D0X2UK
Former ID
DIB014618
Drug Name
Affitope AD-01
Synonyms
AD-01; Amyloid beta 40-42 peptide vaccine (sc, Alzheimer's), AFFiRiS
Drug Type
Vaccine
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1 [522053]
Company
Affiris GmbH
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info [544222]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 522053ClinicalTrials.gov (NCT00495417) Tolerability and Safety of Subcutaneous Administration of Affitope AD01 in Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 544222Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review. Int J Alzheimers Dis. 2012; 2012: 369808.

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