Drug Information

Drug General Information
Drug ID
D0X2XF
Former ID
DNC001122
Drug Name
Piboserod
Drug Type
Small molecular drug
Indication Atrial fibrillation [ICD9: 272, 427.31; ICD10:E78, I48] Phase 2 [521950], [539424]
Structure
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2D MOL

3D MOL
Formula
C22H31N3O2
InChI
InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
InChIKey
KVCSJPATKXABRQ-UHFFFAOYSA-N
CAS Number
CAS 290815-26-8
PubChem Compound ID
177336
PubChem Substance ID
10258594, 14901873, 33500790, 47583796, 47954535, 50614234, 57395380, 85209674, 103385561, 104426309, 128439042, 134339115, 134340342, 134340360, 135133541, 135367549, 135650823, 136351126, 137275879, 141237430, 152049350, 175426880, 179149985, 198990333, 223935693, 226785310
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [535146]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 521950ClinicalTrials.gov (NCT00421746) A Clinical Study Assessing the Potential of Piboserod for the Treatment of Heart Failure. U.S. National Institutes of Health.
Ref 539424(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 225).
Ref 535146Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32.

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