Drug General Information
Drug ID	D0X4CI
Former ID	DNC005187
Drug Name	2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527145]
Structure		Download 2D MOL 3D MOL
Formula	C12H4Br6O2
Canonical SMILES	C1=CC(=C(C=C1Br)Br)OC2=C(C(=C(C(=C2Br)Br)Br)Br)O
InChI	1S/C12H4Br6O2/c13-4-1-2-6(5(14)3-4)20-12-10(18)8(16)7(15)9(17)11(12)19/h1-3,19H
InChIKey	LDMKXEGTHGJWLG-UHFFFAOYSA-N
PubChem Compound ID	9986835
Target and Pathway
Target(s)	Arachidonate 15-lipoxygenase	Target Info	Inhibitor	[527145]
	Arachidonate 12-lipoxygenase, 12S-type	Target Info	Inhibitor	[527145]
BioCyc Pathway	Resolvin D biosynthesis
	Lipoxin biosynthesisPWY66-392:Lipoxin biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Linoleic acid metabolism
	Metabolic pathways
	Serotonergic synapsehsa00590:Arachidonic acid metabolism
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database	IL4-mediated signaling events
PathWhiz Pathway	Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways	Arachidonic acid metabolism
	Eicosanoid SynthesisWP2650:Arachidonic acid metabolism
	Eicosanoid Synthesis
References
Ref 527145	J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Ref 527145	J Med Chem. 2004 Jul 29;47(16):4060-5.Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

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