Drug Information

Drug General Information
Drug ID
D0X5DT
Former ID
DNC007987
Drug Name
2-(2-phenethylphenyl)isoindoline-1,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530220]
Structure
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2D MOL

3D MOL
Formula
C22H17NO2
Canonical SMILES
C1=CC=C(C=C1)CCC2=CC=CC=C2N3C(=O)C4=CC=CC=C4C3=O
InChI
1S/C22H17NO2/c24-21-18-11-5-6-12-19(18)22(25)23(21)20-13-7-4-10-17(20)15-14-16-8-2-1-3-9-16/h1-13H,14-15H2
InChIKey
XGSWAPNRKGOSKD-UHFFFAOYSA-N
PubChem Compound ID
10616182
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [530220]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 530220Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. Epub 2009 Jun 2.Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.
Ref 530220Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. Epub 2009 Jun 2.Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.

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