Drug Information

Drug General Information
Drug ID
D0X5JS
Former ID
DAP001351
Drug Name
Barbituric acid
Synonyms
Barbiturate; Barbitursaeure; Malonylharnstoff; Malonylurea; Pyrimidinetriol; Pyrimidinetrione; Sodium barbiturate; Barbituric acid (VAN); AG-670/31547005; Barbituric acid (VAN) (8CI); Hexahydropyrimidine-2,4,6-trione; Hexahydro-pyrimidine-2,4,6-trione; Pyrimidine-2,4,6(1H,3H,5H)-trione; 1,2,3,4,5,6-Hexahydro-2,4,6-pyrimidinetrione; 1,3-diazinane-2,4,6-trione; 11709_FLUKA; 2,4,6(1H,3H,5H)-Pyrimidinetrione; 2,4,6-(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Pyrimidinetriol; 2,4,6-Pyrimidinetrione; 2,4,6-Trihydroxypyrimidine; 2,4,6-Trioxohexahydropyrimidine; 6-Hydroxyuracil
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [536555]
Therapeutic Class
Antidepressants
Structure
Download
2D MOL

3D MOL
Formula
C4H4N2O3
Canonical SMILES
C1C(=O)NC(=O)NC1=O
InChI
1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)
InChIKey
HNYOPLTXPVRDBG-UHFFFAOYSA-N
CAS Number
CAS 67-52-7
PubChem Compound ID
6211
PubChem Substance ID
4071, 73654, 610615, 839197, 3137537, 3727084, 5630165, 8145676, 8153899, 10532462, 15461893, 24847314, 24851157, 29225209, 48413258, 49857195, 57323260, 57955591, 74498975, 85083143, 85165145, 85247090, 92298605, 103695223, 103811900, 104311418, 104837276, 117593533, 118081819, 124955112, 125308349, 125308617, 125355973, 126546422, 126677922, 127279485, 127279486, 127279487, 127341845, 127341846, 127354639, 131269178, 131323285, 134338565, 134338658, 134970720, 135605431, 136292137, 137006791, 141968478
ChEBI ID
ChEBI:16294
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555], [537688]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 537688Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23.

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