Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X6SZ
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| Former ID |
DPR000053
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| Drug Name |
GNTI
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| Synonyms |
G 3416; GNTI di-trifluoroacetate; Guanidinyl-naltrindole di-trifluoroacetate; 5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate; 5'-Guanidinylnaltrindole dihydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD9: 278; ICD10:E66] | Preclinical | [536122] | ||
| Company |
University of Minneapolis
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| Structure |
|
Download2D MOL |
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| Formula |
C27H30ClN5O3
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| Canonical SMILES |
C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N<br />6)C=CC(=C8)N=C(N)N.Cl
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| InChI |
1S/C27H29N5O3.ClH/c28-25(29)30-15-4-5-18-16(10-15)17-11-27(34)20-9-14-3-6-19(33)23-21(14)26(27,24(35-23)22(17)31-18)7-8-32(20)12-13-1-2-13;/h3-6,10,13,20,24,31,33-34H,1-2,7-9,11-12H2,(H4,28,29,30);1H/t20-,24?,26+,27-;/m1./s1
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| InChIKey |
VNPAGZLSOUNWEV-DXZXNDDESA-N
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| CAS Number |
CAS 219655-56-8
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Kappa-type opioid receptor | Target Info | Antagonist | [536122] | |
| Mu-type opioid receptor | Target Info | Antagonist | [536122] | ||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Enkephalin release | |||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| References | |||||
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