Drug Information

Drug General Information
Drug ID
D0X7MB
Former ID
DIB021004
Drug Name
syn-BrP-LPA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542015]
Structure
Download
2D MOL
Formula
C20H40BrO6P
InChI
InChI=1S/C20H40BrO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(23)27-17-18(22)16-19(21)28(24,25)26/h18-19,22H,2-17H2,1H3,(H2,24,25,26)/t18-,19-/m0/s1
InChIKey
HLVKVWDSLLFMSX-OALUTQOASA-N
PubChem Compound ID
24771259
PubChem Substance ID
49692691, 57271229, 84997356, 178103565, 227753475
Target and Pathway
Target(s) Lysophosphatidic acid receptor Edg-2 Target Info Antagonist [530196]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Gap junction
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Myometrial Relaxation and Contraction Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 542015(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6986).
Ref 530196Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9.

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