Drug Information

Drug General Information
Drug ID
D0X7ZW
Former ID
DIB018241
Drug Name
[3H]apafant
Synonyms
[3H]WEB 2086
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539168]
Structure
Download
2D MOL
Formula
C22H22ClN5O2S
InChI
InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
InChIKey
JGPJQFOROWSRRS-UHFFFAOYSA-N
PubChem Compound ID
65889
PubChem Substance ID
7848715, 7980891, 8190013, 12013921, 14808862, 26753288, 43122628, 47670896, 47744969, 48268088, 49993653, 50545460, 53787682, 57315807, 58108390, 85209803, 85789087, 91610602, 103186311, 103915258, 104334937, 117465116, 124891592, 124891593, 124894328, 126683013, 128272031, 134339496, 135024015, 135649947, 135651137, 135698199, 144206979, 144207143, 162023346, 163124927, 164835912, 170466052, 179149528, 184536613, 198957763, 204356799, 223468665, 223653758, 226471804, 241375892, 252156455, 252214738, 252339034
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [533649]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539168(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1859).
Ref 533649A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31.

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