Drug General Information
Drug ID	D0X8VV
Former ID	DIB001438
Drug Name	Flobufen
Synonyms	VUFB-16066; VUFB-17203
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Phase 3	[534411]
Company	VUFB
Structure		Download 2D MOL 3D MOL
Formula	C17H14F2O3
Canonical SMILES	c1(c(ccc(c1)F)c1ccc(C(=O)CC(C(=O)O)C)cc1)F
CAS Number	CAS 112344-52-2
PubChem Compound ID	159476
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Modulator	[534411]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 534411	Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. 1997 May;47(5):648-52.
Ref 534411	Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. 1997 May;47(5):648-52.

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