Drug Information

Drug General Information
Drug ID
D0X9LK
Former ID
DIB014808
Drug Name
Iralukast
Synonyms
CGP-45715A
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [529458], [541170]
Company
Novartis AG
Structure
Download
2D MOL

3D MOL
Formula
C38H37F3O8S
InChI
InChI=1S/C38H37F3O8S/c1-3-11-29-31(18-17-27(23(2)42)36(29)45)48-19-9-7-5-4-6-8-14-34(35(44)24-12-10-13-25(20-24)38(39,40)41)50-26-15-16-28-30(43)22-33(37(46)47)49-32(28)21-26/h4,6,8,10,12-18,20-22,34-35,44-45H,3,5,7,9,11,19H2,1-2H3,(H,46,47)/b6-4-,14-8+/t34-,35+/m0/s1
InChIKey
IXJCHVMUTFCRBH-SDUHDBOFSA-N
PubChem Compound ID
6913104
PubChem Substance ID
14864293, 23950749, 43525817, 50803562, 114777695, 160687820, 178102485, 198950191, 232161526
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [534582]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529458Iralukast Novartis AG. IDrugs. 1998 May;1(1):147-50.
Ref 541170(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5861).
Ref 534582Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. Br J Pharmacol. 1998 Feb;123(3):590-8.

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