TTD | Drug: D0X9YS

Drug General Information
Drug ID	D0X9YS
Former ID	DIB018888
Drug Name	AS-19
Synonyms	AS 19; AS19
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529256]
Structure		Download 2D MOL
Formula	C18H25N3
InChI	InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1
InChIKey	BTTOYOKCLDAHHO-HNNXBMFYSA-N
PubChem Compound ID	23642275
PubChem Substance ID	46502276, 103918438, 137006646, 162220293, 163334533, 226619003, 241375716, 243382257, 249617456, 252156224, 252166643
Target and Pathway
Target(s)	5-hydroxytryptamine 7 receptor	Target Info	Agonist	[532288]
KEGG Pathway	Ras signaling pathway
	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome	Serotonin receptors
Reactome	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 529256	The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195(1):112-9.
Ref 532288	Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorg Med Chem. 2013 May 1;21(9):2568-76.

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Drug Information