Drug Information

Drug General Information
Drug ID
D0XC6G
Former ID
DNC006712
Drug Name
2-(1H-indazol-3-yl)-1H-benzo[d]imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528122]
Structure
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2D MOL

3D MOL
Formula
C14H10N4
Canonical SMILES
C1=CC=C2C(=C1)C(=C3N=C4C=CC=CC4=N3)NN2
InChI
1S/C14H10N4/c1-2-6-10-9(5-1)13(18-17-10)14-15-11-7-3-4-8-12(11)16-14/h1-8,17-18H
InChIKey
ULAJWYXWWHKJNG-UHFFFAOYSA-N
PubChem Compound ID
5327123
Target and Pathway
Target(s) Basic fibroblast growth factor receptor 1 Target Info Inhibitor [528122]
Beta platelet-derived growth factor receptor Target Info Inhibitor [528122]
mRNA of VEGFR1 Target Info Inhibitor [528122]
Vascular endothelial growth factor receptor 2 Target Info Inhibitor [528122]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Proteoglycans in cancer
Prostate cancer
Melanoma
Central carbon metabolism in cancerhsa04010:MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Focal adhesion
Gap junction
HTLV-I infection
MicroRNAs in cancer
Glioma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Endocytosis
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
VEGF signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
FGF signaling pathwayP00005:Angiogenesis
PDGF signaling pathwayP00005:Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathwayptp1bpathway:Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkglypican_1pathway:Glypican 1 network
HIF-2-alpha transcription factor network
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY network
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WikiPathways Regulation of Actin Cytoskeleton
Endochondral Ossification
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
Neural Crest Differentiation
Signaling by FGFRWP51:Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
PIP3 activates AKT signaling
PDGF Pathway
Signaling by PDGFWP306:Focal Adhesion
Signaling by VEGF
AngiogenesisWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Angiogenesis
References
Ref 528122Bioorg Med Chem Lett. 2006 Jul 1;16(13):3595-9. Epub 2006 Apr 5.Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases.
Ref 528122Bioorg Med Chem Lett. 2006 Jul 1;16(13):3595-9. Epub 2006 Apr 5.Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases.

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