Drug Information

Drug General Information
Drug ID
D0XH1N
Former ID
DIB020034
Drug Name
ICA-105574
Synonyms
ICA 105574; ICA105574
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542634]
Structure
Download
2D MOL
Formula
C19H14N2O4
InChI
InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
InChIKey
GDWKBKTVROCPNZ-UHFFFAOYSA-N
PubChem Compound ID
715924
PubChem Substance ID
929159, 6032710, 9299757, 27110510, 33773926, 47461836, 48090774, 50598192, 88881617, 105962120, 109896267, 117378658, 126830748, 137212823, 143717368, 162248884, 163477128, 163798271, 164921681, 166294472, 173901225, 223365991, 244330254
Target and Pathway
Target(s) Kv10.1 Target Info Inhibitor (gating inhibitor) [532196]
Potassium voltage-gated channel subfamily H member 2 Target Info Activator [530426]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 542634(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7656).
Ref 530426Pharmacological removal of human ether-?-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol. 2010 Jan;77(1):58-68.
Ref 532196ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Mol Pharmacol. 2013 Apr;83(4):805-13.

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