Drug Information

Drug General Information
Drug ID
D0XJ6D
Former ID
DNC003598
Drug Name
4-(3-Methyl-indole-1-sulfonyl)-phenylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527463]
Structure
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2D MOL

3D MOL
Formula
C15H14N2O2S
Canonical SMILES
CC1=CN(C2=CC=CC=C12)S(=O)(=O)C3=CC=C(C=C3)N
InChI
1S/C15H14N2O2S/c1-11-10-17(15-5-3-2-4-14(11)15)20(18,19)13-8-6-12(16)7-9-13/h2-10H,16H2,1H3
InChIKey
ZNRJXSHXWJKTGJ-UHFFFAOYSA-N
PubChem Compound ID
10356663
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527463]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527463Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.
Ref 527463Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.

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