Drug Information

Drug General Information
Drug ID
D0XX5S
Former ID
DNC012248
Drug Name
DICHLOROISOPROTERENOL
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533801]
Structure
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2D MOL

3D MOL
Formula
C11H15Cl2NO
Canonical SMILES
CC(C)NCC(C1=CC(=C(C=C1)Cl)Cl)O
InChI
1S/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3
InChIKey
VKMGSWIFEHZQRS-UHFFFAOYSA-N
PubChem Compound ID
5806
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Inhibitor [533801]
Beta-1 adrenergic receptor Target Info Inhibitor [533801]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretionhsa04020:Calcium signaling pathway
Gap junction
Salivary secretion
Dilated cardiomyopathy
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Endothelin Pathways
References
Ref 533801J Med Chem. 1994 May 13;37(10):1518-25.The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists.
Ref 533801J Med Chem. 1994 May 13;37(10):1518-25.The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists.

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