Drug Information

Drug General Information
Drug ID
D0Y0BK
Former ID
DNC014891
Drug Name
DORSOMORPHIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468093]
Structure
Download
2D MOL

3D MOL
Formula
C24H25N5O
InChI
InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChIKey
XHBVYDAKJHETMP-UHFFFAOYSA-N
PubChem Compound ID
11524144
PubChem Substance ID
16626128, 23651006, 24898658, 26740883, 26758223, 26758224, 29217627, 53786887, 53800969, 53800970, 75175553, 85788231, 98570042, 99302626, 99431644, 99445068, 103623641, 104111291, 104548349, 119524662, 121279095, 124893194, 125503629, 126661319, 131328479, 131538258, 134352096, 135282172, 135711804, 136899197, 137864951, 160835058, 160969630, 163230883, 163400671, 163688604, 163688605, 164041743, 166200007, 172821450, 174006502, 175607457, 178101606, 179694515, 204384696, 208265176, 210274852, 210280484, 223443838, 223573618
Target and Pathway
Target(s) AMP-activated protein kinase Target Info Inhibitor [531199]
KEGG Pathway FoxO signaling pathway
Regulation of autophagy
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Circadian rhythm
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hypertrophic cardiomyopathy (HCM)
Reactome Translocation of GLUT4 to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
TP53 Regulates Metabolic Genes
WikiPathways Insulin Signaling
Energy dependent regulation of mTOR by LKB1-AMPK
JAK/STAT
BDNF signaling pathway
Leptin signaling pathway
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
References
Ref 468093(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4907).
Ref 531199Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity.

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