Drug Information

Drug General Information
Drug ID
D0Y0JH
Former ID
DAP000734
Drug Name
Salsalate
Synonyms
Diacesal; Diplosal; Disalcid; Disalicylsaeure; Disalyl; Nobacid; Salflex; Salical; Salina; Saloxium; Salsalato; Salsalatum;Salysal; Sasapirin; Sasapyrin; Sasapyrine; Sasapyrinum; Disalicylic acid; Sal Ester Sal; Salicylic Acid Salicylate; Salicyloylsalicylic acid; Salicylsalicylic acid; Disalcid (TN); O-Salicylcylsalicylsaeure; O-Salicyloylsalicylic Acid; O-Salicylsalicylic acid; Salflex (TN); Salicylic acid, bimolecular ester; Salicylic acid, salicylate; Salsalato [INN-Spanish]; Salsalatum [INN-Latin]; Salsitab (TN); Sasapyrine (JAN); Mono-Gesic (TN); Salsalate (USP/INN); Salsalate [USAN:INN:BAN]; Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; 2-((2-Hydroxybenzoyl)oxy)benzoic acid; 2-(2-hydroxybenzoyl)oxybenzoic acid; 2-Carboxyphenyl salicylate; 2-Salicyloyloxybenzoic Acid; 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid
Drug Type
Small molecular drug
Indication Rheumatold arthritis; Osteoarthritis [ICD9: 714, 715; ICD10:M05-M06, M15-M19, M47] Approved [550688], [551871]
Therapeutic Class
Antiinflammatory Agents
Structure
Download
2D MOL

3D MOL
Formula
C14H10O5
Canonical SMILES
C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O
InChI
1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
InChIKey
WVYADZUPLLSGPU-UHFFFAOYSA-N
CAS Number
CAS 552-94-3
PubChem Compound ID
5161
PubChem Substance ID
101463, 220693, 3134440, 5591035, 7847494, 8153173, 10526880, 11364971, 11367533, 11370095, 11371265, 11374638, 11378266, 11484581, 11488509, 11489989, 11492755, 11495812, 14798887, 26613017, 26679829, 26683807, 26750031, 29224223, 46506882, 47216943, 47885574, 48416531, 49887489, 50107792, 57322633, 76311971, 87575737, 92307195, 92716557, 103401161, 103848157, 104308445, 107915682, 117574614, 118266874, 124585059, 124637486, 125353002, 126622839, 126654325, 126677823, 129642109, 134222723, 134338021
SuperDrug ATC ID
N02BA06
SuperDrug CAS ID
cas=000552943
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Inhibitor [535987], [538120]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 550688Drug information of Salsalate, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535987Aspirin and NSAID sensitivity. Immunol Allergy Clin North Am. 2004 Aug;24(3):491-505, vii.
Ref 538120New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase. Med Klin (Munich). 1998 Jul 15;93(7):407-15.

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